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Experts show how to 'eat less and be full for a long time', lose weight effectively

New research has discovered an enzyme that plays an important role in making us feel full, which could be the target of a drug to control obesity.

Researchers have identified a mechanism that could help successfully treat obesity by making overweight people feel full when they eat less.

A multinational research team at Hong Kong Baptist University, Chinese University of Hong Kong, University of Texas and University of Helsinki has discovered an enzyme that plays an important role in appetite regulation and says , this enzyme could be developed into drugs to help control obesity.

The most effective way to tackle obesity is to eat less, but obese people often have difficulty adjusting their eating habits, as they lose their sense of fullness.

Scientists led by Dr Xavier Wong Hoi-leong and Professor Bian Zhaoxiang have identified an enzyme that can modulate satiety signals in the brain to help regulate food intake, named it matrix metalloproteinase type 1 (MT1-MMP).

Dr Wong said the study results identified a role for MT1-MMP in the regulation of satiety and provide indications that it is a promising target for the treatment of obesity.

The scientists generated a group of obese mice by feeding them a high-fat diet while depleting MT1-MMP in their satiety neurons and feeding the normal group of mice the same diet. diet.

After 16 weeks, MT1-MMP-depleted mice ate 10% less food, gained 50% less weight, and had lower plasma glucose and insulin levels than controls.

The results showed that MT1-MMP depletion protected mice against obesity when they ate a high-fat diet.

Obese people often have difficulty regulating their eating habits, as they lose their sense of fullness.

The team also found that the obese mice had increased MT1-MMP activity in brain regions involved in appetite and weight regulation.

Laboratory testing of obese mice showed that they ate less after being administered a specific neutralizing antibody that inhibits MT1-MMP.

As a result, MT1-MMP is a potential target that can be used to develop innovative drug treatments for obesity .

The study comes at a time when experts are warning that an increasing number of people are falling ill because of a sedentary diet and lifestyle, leading to a sharp increase in non-communicable diseases such as hypertension, high blood pressure, and high blood pressure. diabetes and high cholesterol levels.

Professor Martin Wong, a specialist in non-communicable diseases at the Chinese University of Hong Kong, said: "This has to do with eating and physical habits . People are more sedentary, living a sedentary lifestyle. , don't exercise. During the peak of the COVID-19 pandemic, people stay at home most of the time."


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